February
1. Alcaro, S.; Bolognesi, ML.; García-Sosa, AT.; Rapposelli, S. Editorial: Multi-Target-Directed Ligands (MTDL) as Challenging Research Tools in Drug Discovery: From Design to Pharmacological Evaluation. Front Chem 2019, 7, 71. DOI: 10.3389/fchem.2019.00071
March
2. Roleira, FMF.; Varela, C.; Amaral, C.; Costa, SC.; Correia-da-Silva, G.; Moraca, F.; Costa, G.; Alcaro, S.; Teixeira, NAA.; Tavares da Silva, EJ. C-6α- vs C-7α-Substituted Steroidal Aromatase Inhibitors: Which Is Better? Synthesis, Biochemical Evaluation, Docking Studies, and Structure-Activity Relationships. J Med Chem 2019, 62, 3636-3657. DOI: 10.1021/acs.jmedchem.9b00157
June
3. Koziolek, M.; Alcaro, S.; Augustijns, P.; Basit, AW.; Grimm, M.; Hens, B.; Hoad, CL.; Jedamzik, P.; Madla, CM.; Maliepaard, M.; Marciani, L.; Maruca, A.; Parrott, N.; Pávek, P.; Porter, CJH.; Reppas, C.; van Riet-Nales, D.; Rubbens, J.; Statelova, M.; Trevaskis, NL.; Valentová, K.; Vertzoni, M.; Čepo, DV.; Corsetti, M. The mechanisms of pharmacokinetic food-drug interactions – A perspective from the UNGAP group. Eur J Pharm Sci 2019, 134, 31-59. DOI: 10.1016/j.ejps.2019.04.003
July
4. Oliveira, C.; Bagetta, D.; Cagide, F.; Teixeira, J.; Amorim, R.; Silva, T.; Garrido, J.; Remião, F.; Uriarte, E.; Oliveira, PJ.; Alcaro, S.; Ortuso, F.; Borges, F. Benzoic acid-derived nitrones: A new class of potential acetylcholinesterase inhibitors and neuroprotective agents. Eur J Med Chem 2019, 174, 116-129. DOI: 10.1016/j.ejmech.2019.04.026
August
5. Guglielmi, P.; Secci, D.; Petzer, A.; Bagetta, D.; Chimenti, P.; Rotondi, G.; Ferrante, C.; Recinella, L.; Leone, S.; Alcaro, S.; Zengin, G.; Petzer, JP.; Ortuso, F.; Carradori, S. Benzo[b]tiophen-3-ol derivatives as effective inhibitors of human monoamine oxidase: design, synthesis, and biological activity. J Enzyme Inhib Med Chem 2019, 34, 1511-1525.
DOI: 10.1080/14756366.2019.1653864
November
6. Costa, G.; Carta, F.; Ambrosio, FA.; Artese, A.; Ortuso, F.; Moraca, F.; Rocca, R.; Romeo, I.; Lupia, A.; Maruca, A.; Bagetta, D.; Catalano, R.; Vullo, D.; Alcaro, S.; Supuran, CT. A computer-assisted discovery of novel potential anti-obesity compounds as selective carbonic anhydrase VA inhibitors. Eur J Med Chem 2019, 181, 111565. DOI: 10.1016/j.ejmech.2019.111565
7. Maruca, A.; Catalano, R.; Bagetta, D.; Mesiti, F.; Ambrosio, FA.; Romeo, I.; Moraca, F.; Rocca, R.; Ortuso, F.; Artese, A.; Costa, G.; Alcaro, S.; Lupia, A. The Mediterranean Diet as source of bioactive compounds with multi-targeting anti-cancer profile. Eur J Med Chem 2019, 181, 111579. DOI: 10.1016/j.ejmech.2019.111579
8. Esposito, F.; Ambrosio, FA.; Maleddu, R.; Costa, G.; Rocca, R.; Maccioni, E.; Catalano, R.; Romeo, I.; Eleftheriou, P.; Karia, DC.; Tsirides, P.; Godvani, N.; Pandya, H.; Corona, A.; Alcaro, S.; Artese, A.; Geronikaki, A.; Tramontano, E. Chromenone derivatives as a versatile scaffold with dual mode of inhibition of HIV-1 reverse transcriptase-associated Ribonuclease H function and integrase activity. Eur J Med Chem 2019, 182, 111617.
DOI: 10.1016/j.ejmech.2019.111617
9. Catalano, R.; Moraca, F.; Amato, J.; Cristofari, C.; Rigo, R.; Via, LD.; Rocca, R.; Lupia, A.; Maruca, A.; Costa, G.; Catalanotti, B.; Artese, A.; Pagano, B.; Randazzo, A.; Sissi, C.; Novellino, E.; Alcaro, S. Targeting multiple G-quadruplex-forming DNA sequences: Design, biophysical and biological evaluations of indolo-naphthyridine scaffold derivatives. Eur J Med Chem 2019, 182, 111627. DOI: 10.1016/j.ejmech.2019.111627
10. Mesiti, F.; Chavarria, D.; Gaspar, A.; Alcaro, S.; Borges, F. The chemistry toolbox of multitarget-directed ligands for Alzheimer’s disease. Eur J Med Chem 2019, 181, 111572. DOI: 10.1016/j.ejmech.2019.111572
December
11. Catalano, R.; Rocca, R.; Juli, G.; Costa, G.; Maruca, A.; Artese, A.; Caracciolo, D.; Tagliaferri, P.; Alcaro, S.; Tassone, P.; Amodio, N. A drug repurposing screening reveals a novel epigenetic activity of hydroxychloroquine. Eur J Med Chem 2019, 183, 111715. DOI: 10.1016/j.ejmech.2019.111715
12. Catalogna, G.; Moraca, F.; D’Antona, L.; Dattilo, V.; Perrotti, G.; Lupia, A.; Costa, G.; Ortuso, F.; Iuliano, R.; Trapasso, F.; Amato, R.; Alcaro, S.; Perrotti, N. Review about the multi-target profile of resveratrol and its implication in the SGK1 inhibition. Eur J Med Chem 2019, 183, 111675. DOI: 10.1016/j.ejmech.2019.111675